A/Prof Severine Navarro ~

Dr Severine Navarro has been appointed as a Senior Research Fellow at the Australian Institute of Tropical Health and Medicine, James Cook University, in the laboratory of Professor Alex Loukas. The focus of her research project is the development of hookworm protein-based therapeutics for the treatment of chronic inflammatory diseases such as allergic asthma, inflammatory bowel diseases and Celiac disease.  She has obtained her PhD with high honors in 2011 at the Universite de Nice-Sophia-Antipolis, France where she used different approaches to induce and recruit regulatory T cells to the airways and suppress allergic inflammation.

Prior to her PhD, she obtained a Master's degree in Developmental Biology, Genetics and Immunology from the Universite de Nice-Sophia-Antipolis, France and based her thesis on the visualisation in vivo of peptide/MHC II complexes at the surface of antigen presenting cells. She obtained before that a bachelor's degree in Molecular Biology and a second one in General Biology from the Florida Institute of Technology, USA.

Interests

Research

• Chronic inflammatory diseases
• Allergic asthma
• Development of novel therapeutics
• Inflammatory bowel diseases
• Coeliac disease
• Microbiota
• Mucosal Immunology

Experience

• 2017 to present - Children's Hospital Foundation Fellow, AITHM, James Cook University (Cairns, QLD, Australia)
• 2011 to 2016 - Research Fellow, CBMDT, AITHM, James Cook University (Cairns, QLD, Australia)
• 2009 to 2010 - University Lecturer, Skema Business School (Sophia-Antipolis, France)
• 2006 to 2010 - PhD Immunology, Institut de Pharmacologie Moleculaire et Cellulaire, Universite de Nice Sophia Antipolis (Nice, France)
• 2006 to 2009 - University Lecturer, Universite de Nice-Sophia-Antipolis (Nice, France)
• 2005 to 2006 - Master's Immunity, Genetics and Developmental Biology, Institut de Pharmacologie Moleculaire et Cellulaire, Universite de Nice-Sophia-Antipolis (Nice, France)
• 2003 to 2005 - Research Assistant / Lab Manager, Center for Environmental Health Sciences, University of Montana (Missoula, MT, USA)

Research Disciplines

• Immunology (3204)
• Medicinal and biomolecular chemistry (3404)
• Medical biochemistry and metabolomics (3205)

Socio-Economic Objectives

• Clinical health (2001)
• Expanding knowledge (2801)

Awards

• 2012 - Australian Society of Parasitology Research and Scientific Exchange award
• 2012 - Uniquest Trailblazer – highly commended award
• 1999 to 2002 - Florida Institute of Technology Scholar merit award

Fellowships

• 2006 to 2010 - National doctoral fellowship award, top ten best student merit fellowships

These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.

Journal Articles

• Cobos C, Bansal P, Wilson D, Jones L, Zhao G, Field M, Eichenberger R, Pickering D, Ryan R, Ratnatunga C, Miles J, Ruscher R, Giacomin P, Navarro S, Loukas A and Daly N (2022) Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells. Frontiers in Medicine, 9.
• Smallwood T, Navarro S, Cristofori-Armstrong B, Watkins T, Tungatt K, Ryan R, Haigh O, Lutzky V, Mulvenna J, Rosengren K, Loukas A, Miles J and Clark R (2021) Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1).
• Horwood P, Tarantola A, Goarant C, Matsui M, Klement E, Umezaki M, Navarro S and Greenhill A (2019) Health challenges of the Pacific Region: insights from history, geography, social determinants, genetics, and the microbiome. Frontiers in Immunology, 10.
• Logan J, Navarro S, Loukas A and Giacomin P (2018) Helminth-induced regulatory T cells and suppression of allergic responses. Current Opinion in Immunology, 54. pp. 1-6
• Muruganandah V, Sathkumara H, Navarro S and Kupz A (2018) A systematic review: the role of resident memory T cells in infectious diseases and their relevance for vaccine development. Frontiers in Immunology, 9. pp. 1-21
• Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A and Wangchuk P (2018) A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis. Journal of Ethnopharmacology, 211. pp. 17-28
• Cobos Caceres C, Bansal P, Navarro S, Wilson D, Don L, Giacomin P, Loukas A and Daly N (2017) An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease. Journal of Biological Chemistry, 292 (24). pp. 10288-10294
• Ferreira I, Pickering D, Troy S, Croese J, Loukas A and Navarro S (2017) Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis. Clinical & Translational Immunology, 6.
• Sotillo J, Ferreira I, Potriquet J, Laha T, Navarro S, Loukas A and Mulvenna J (2017) Changes in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis. Scientific Reports, 7.
• Liu T, Navarro S and Lopata A (2016) Current advances of murine models for food allergy. Molecular Immunology, 70. pp. 104-117
• Navarro S, Pickering D, Ferreira I, Jones L, Ryan S, Troy S, Leech A, Hotez P, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda C, Upham J, Julia V, Giacomin P and Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine, 8 (362).
• Susilawati T, Jex A, Cantacessi C, Pearson M, Navarro S, Susianto A, Loukas A and McBride W (2016) Deep sequencing approach for investigating infectious agents causing fever. European Journal of Clinical Microbiology and Infectious Diseases, 35 (7). pp. 1137-1149

More

ResearchOnline@JCU stores 25+ research outputs authored by A/Prof Severine Navarro from 2006 onwards.

Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.

These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.

Current

• Nutritional Modification of Gestational Neurodevelopmental Programming: The Impact on Offspring Mental Health Related Behaviours in a Translational Mouse Model (PhD , Secondary Advisor)
• Identification and influence of intestinal parasites in the gut microbiome of mothers and infants from Papua New Guinea. (PhD , Primary Advisor)

Completed

• Characterisation of Necator americanus excretory/secretory products (2020, PhD , Secondary Advisor)

The map shows research collaborations by institution from the past 7 years.
Note: Map points are indicative of the countries or states that institutions are associated with.